Remodelling of fibrillin-rich microfibrils by solar-simulated radiation: impact of skin ethnicity

Author:

Langton Abigail K.12345ORCID,Hann Mark6734,Costello Patrick1234,Halai Poonam1234,Griffiths Christopher E. M.12345,Sherratt Michael J.874,Watson Rachel E. B.12345ORCID

Affiliation:

1. Centre for Dermatology Research

2. The University of Manchester & Salford Royal NHS Foundation Trust

3. Manchester Academic Health Science Centre

4. UK

5. NIHR Manchester Biomedical Research Centre

6. Centre for Biostatistics

7. The University of Manchester

8. Division of Cell Matrix Biology and Regenerative Medicine

Abstract

Cutaneous fibrillin-rich microfibrils (FRMs) should be considered as two distinct populations that differentially accrue damage in response to SSR. Furthermore, FRMs derived from black African skin show greater change following UVR challenge.

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry

Reference36 articles.

1. The Biomechanical Properties of the Skin

2. R. P. Mecham and E. C.Davis , in Extracellular matrix assembly and structure , ed. P. D. Yurchenco , D. E. Birk and R. P. Mecham , Academic Press , New York , 1994 , pp. 281–314

3. Extraction of extendable beaded structures and their identification as fibrillin-containing extracellular matrix microfibrils.

4. Structural and compositional diversity of fibrillin microfibrils in human tissues

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