DOX-loaded pH-sensitive mesoporous silica nanoparticles coated with PDA and PEG induce pro-death autophagy in breast cancer

Author:

Duo Yanhong12345ORCID,Li Yang678910,Chen Changke1112131415,Liu Baiyun12345,Wang Xinyu12345,Zeng Xiaowei1112131415ORCID,Chen Hongbo16171810

Affiliation:

1. Key Laboratory of Plant Cell Activities and Stress Adaptation

2. Ministry of Education

3. School of Life Sciences

4. Lanzhou University

5. Lanzhou 730000

6. Department of Hepatobiliary and Pancreas Surgery

7. Second Clinical Medical College of Jinan University

8. Shenzhen People's Hospital

9. Shenzhen 518000

10. P. R. China

11. The Shenzhen Key Lab of Gene and Antibody Therapy

12. Division of Life and Health Sciences

13. Graduate School at Shenzhen

14. Tsinghua University

15. Shenzhen 518055

16. School of Pharmaceutical Sciences (Shenzhen)

17. Sun Yat-sen University

18. Guangzhou 510275

Abstract

The development of multifunctional nano drug delivery carriers has been one of the most effective and prevailing approaches to overcome drug non-selectivity, low cell uptake efficiency and various side effects of traditional chemotherapy drugs.

Funder

Guandong Natural Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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