Microwave-assisted synthesis, biological evaluation and molecular docking studies of new coumarin-based 1,2,3-triazoles

Author:

Dharavath Ravinder12345,Nagaraju Nalaparaju12345,Reddy M. Ram12345,Ashok D.12345ORCID,Sarasija M.2675,Vijjulatha M.82345,T Vani82345,Jyothi K.910115,Prashanthi G.910115

Affiliation:

1. Green and Medicinal Chemistry Lab

2. Department of Chemistry

3. Osmania University

4. Hyderabad-500007

5. India

6. Satavahana University

7. Karimnagar-505001

8. Molecular Modelling and Medicinal Chemistry Group

9. Department of Pharmaceutical Chemistry

10. St Mary's College of Pharmacy

11. Secunderabad-500025

Abstract

Coumarin-based 1,4-disubstituted 1,2,3-triazole derivatives were synthesized using a highly efficient, eco-friendly protocol via a copper(i)-catalyzed click reaction between various substituted arylazides and terminal alkynes.

Funder

Council of Scientific and Industrial Research, India

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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1. Click synthesis, anticancer and molecular docking evaluation of some hexahydro-6H-indolo[2,3-b]quinoxalines incorporated triazole moiety;Journal of Molecular Structure;2024-05

2. Synthesis of coumarin derivatives via knoevenagel condensation under microwave irradiation;PROCEEDINGS OF THE 2ND INTERNATIONAL INTERDISCIPLINARY SCIENTIFIC CONFERENCE “DIGITALIZATION AND SUSTAINABILITY FOR DEVELOPMENT MANAGEMENT: ECONOMIC, SOCIAL, AND ENVIRONMENTAL ASPECTS”;2024

3. Green synthesis of 1,4-disubstituted 1,2,3-triazoles: a sustainable approach;Green Chemistry;2024

4. Strategic application of CuAAC click chemistry in the modification of natural products for anticancer activity;European Journal of Medicinal Chemistry Reports;2023-12

5. Development of Novel Indole and Coumarin Derivatives as Antibacterial Agents That Target Histidine Kinase in S. aureus;Applied Microbiology;2023-10-17

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