Additive-free regio- and diastereoselective construction of fully-substituted isoxazolidines employing diazo compounds

Author:

Gupta Ekta1234,Zaheer Mohd Khalid1234,Kant Ruchir5234,Mohanan Kishor12346ORCID

Affiliation:

1. Medicinal and Process Chemistry Division

2. CSIR-Central Drug Research Institute

3. Lucknow 226031

4. India

5. Molecular and Structural Biology Division

6. Academy of Scientific and Innovative Research

Abstract

An efficient additive-free three-component access to densely functionalized isoxazolidines using diazo compounds, nitrosoarene, and allenic esters has been uncovered.

Funder

Science and Engineering Research Board

Council of Scientific and Industrial Research, India

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Reference55 articles.

1. Recent Developments in Nitrone Chemistry: Some Novel Transformations

2. 1,3-Dipolar Cycloadditions of Nitrones to Heterosubstituted Alkenes. Part 1: Oxa and Aza-substituted Alkenes

3. R. C. F. Jones and J. N.Martin , in Synthetic Applications of 1,3-Dipolar Cycloadditions. Chemistry Toward Heterocycles and Natural Products , ed. A. Padwa and W. H. Pearson , John Wiley & Sons , Hoboken, NJ , 2003 , ch. 1

4. Catalytic enantioselective 1,3-dipolar cycloaddition reactions of nitrones

5. Asymmetric 1,3-Dipolar Cycloaddition Reactions

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