Protein cohabitation: long-term immunoglobulin G storage at room temperature

Author:

Bharmoria Pankaj123ORCID,Ooi Saik Ann1ORCID,Cellini Andrea1ORCID,Tietze Daniel1ORCID,Maj Michal4ORCID,Moth-Poulsen Kasper2356ORCID,Tietze Alesia A.1ORCID

Affiliation:

1. Department of Chemistry and Molecular Biology, University of Gothenburg, Kemigården 10, 412 96, Gothenburg, Sweden

2. Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemivägen 4, 412 96, Gothenburg, Sweden

3. The Institute of Materials Science of Barcelona, ICMAB-CSIC, Bellaterra, 08193, Barcelona, Spain

4. Department of Chemistry – Ångström Laboratory, Physical Chemistry, Lägerhyddsvägen 1, 751 20 Uppsala, Sweden

5. Catalan Institution for Research & Advanced Studies, ICREA, Pg. Lluís Companys 23, Barcelona, Spain

6. Department of Chemical Engineering, Universitat Politècnica de Catalunya, EEBE, Eduard Maristany 10–14, 08019 Barcelona, Spain

Abstract

We report a simple bioinspired strategy of protein cohabitation for long-term functional storage of therapeutic proteins at room temperature.

Funder

Vetenskapsrådet

Knut och Alice Wallenbergs Stiftelse

H2020 Marie Skłodowska-Curie Actions

“la Caixa” Foundation

Institució Catalana de Recerca i Estudis Avançats

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Reference62 articles.

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4. Structure and function of immunoglobulins

5. C. A.Janeway Jr , P.Travers , M.Walport and M. J.Shlomchik , The structure of a typical antibody molecule. In Immunobiology: The Immune System in Health and Disease , Garland Science , 5th edn, 2001

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