Investigation of some benzoquinazoline and quinazoline derivatives as novel inhibitors of HCV-NS3/4A protease: biological, molecular docking and QSAR studies-Reference-Cited by-同舟云学术

Investigation of some benzoquinazoline and quinazoline derivatives as novel inhibitors of HCV-NS3/4A protease: biological, molecular docking and QSAR studies

Published:2020 Issue:59 Volume:10 Page:35820-35830
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Abuelizz Hatem A.¹²³⁴⁵^ORCID,Marzouk Mohamed⁶⁷⁸⁹¹⁰,Bakheit Ahmed H.¹²³⁴⁵,Al-Salahi Rashad¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry

2. College of Pharmacy

3. King Saud University

4. Riyadh 11451

5. Saudi Arabia

6. Chemistry of Natural Products Group

7. Center of Excellence for Advanced Sciences

8. National Research Centre

9. Cairo 12622

10. Egypt

Abstract

HCV NS3/A4 protease inhibitors are one of the best therapeutic targets for the identification of novel candidate drugs. A series of benzo[g]quinazolines and their quinazoline analogues were evaluated for their HCV-NS3/4A inhibitory activities.

Funder

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA05604A

Reference32 articles.

1. Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides

2. Evolution, synthesis and SAR of tripeptide α-ketoacid Inhibitors of the hepatitis C virus NS3/NS4A serine protease

3. Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides