Solvent-free mechanochemical grinding facilitates clean synthesis of <i>N</i>-substituted amines-Reference-Cited by-同舟云学术

Solvent-free mechanochemical grinding facilitates clean synthesis of N-substituted amines

Published:2022 Issue:33 Volume:20 Page:6673-6679
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Sharma Neha¹,Sharma Himanshi¹,Kumar Manoj¹,Grishina Maria²,Pandit Unnat³,Poonam ⁴^ORCID,Rathi Brijesh¹^ORCID

Affiliation:

1. Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College, University of Delhi, Delhi, 110007, India

2. South Ural State University, Laboratory of Computational Modelling of Drugs, Pr. Lenina, 76 454080, Russia

3. Special Centre for Systems Medicine, Jawaharlal Nehru University, New Delhi 110067, India

4. Department of Chemistry, Miranda House, University of Delhi, Delhi-110007, India

Abstract

We optimized a solvent-free mechanochemical grinding procedure for the synthesis of N-substituted amines. The method involves mild reaction conditions and isolation of products without column chromatography.

Funder

Russian Foundation for Basic Research

Council of Scientific and Industrial Research, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01148D

Reference31 articles.

1. Warming up for mechanosynthesis – temperature development in ball mills during synthesis

2. Facile reduction of carboxylic acids to primary alcohols under catalyst-free and solvent-free conditions

3. Catalyst- and solvent-free efficient access to N-alkylated amines via reductive amination using HBpin

4. Metrics of green chemistry: Waste minimization

5. A Method for Assessing Greener Alternatives between Chemical Products Following the 12 Principles of Green Chemistry

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