Single-domain antibody C7b for address delivery of nanoparticles to HER2-positive cancers

Author:

Vorotnikov Yuri A.123ORCID,Novikova Evgeniya D.123,Solovieva Anastasiya O.453,Shanshin Daniil V.673,Tsygankova Alphiya R.123ORCID,Shcherbakov Dmitrii N.67389,Efremova Olga A.4531011ORCID,Shestopalov Michael A.123ORCID

Affiliation:

1. Nikolaev Institute of Inorganic Chemistry SB RAS

2. 630090 Novosibirsk

3. Russian Federation

4. Research Institute of Clinical and Experimental Lymphology – branch of ICG SB RAS

5. 630060 Novosibirsk

6. State Research Center of Virology and Biotechnology VECTOR

7. Koltsovo

8. Russian-American Anti-Cancer Center

9. Altai State University

10. The Federal Research Center of Fundamental and Translational Medicine

11. 630117 Novosibirsk

Abstract

Single-domain antibody C7b is benchmarked against trastuzumab for targeted delivery of photoactive silica nanoparticles to a HER2 overexpressing cancer cell line and tissue.

Funder

Russian Science Foundation

Royal Society

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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