The neuroleptic drug fluphenazine induces a significant UVA-mediated cytotoxic effect on three human cancer cell lines through apoptosis
Author:
Affiliation:
1. Department of Pharmaceutical and Pharmacological Sciences
2. University of Padova
3. 35131 Padova
4. Italy
Abstract
The cytotoxic activity of fluphenazine (FPZ) in combination with UVA light was evaluated on three human tumor cell lines, HeLa, MSTO-211H and A431.
Publisher
Springer Science and Business Media LLC
Subject
Physical and Theoretical Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/PP/C9PP00023B
Reference13 articles.
1. A. Brayfield , Martindale: The Complete Drug Reference , Pharmaceutical Press , 39th edn, 2014
2. Mitochondria and plasma membrane as targets of UVA-induced toxicity of neuroleptic drugs fluphenazine, perphenazine and thioridazine
3. Photoaddition of Fluphenazine to Nucleophiles in Peptides and Proteins. Possible Cause of Immune Side Effects
4. Photosensitization of DNA Strand Breaks by Three Phenothiazine Derivatives
5. Excited-state Properties and In Vitro Phototoxicity Studies of Three Phenothiazine Derivatives¶
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1. Phenothiazine derivatives and their impact on the necroptosis and necrosis processes. A review;Toxicology;2023-06
2. Antipsychotic Drug Fluphenazine against Human Cancer Cells;Biomolecules;2022-09-23
3. Targeting Reactive Oxygen Species Capacity of Tumor Cells with Repurposed Drug as an Anticancer Therapy;Oxidative Medicine and Cellular Longevity;2021-09-07
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