Dual controlled delivery of squalenoyl-gemcitabine and paclitaxel using thermo-responsive polymeric micelles for pancreatic cancer-Reference-Cited by-同舟云学术

Dual controlled delivery of squalenoyl-gemcitabine and paclitaxel using thermo-responsive polymeric micelles for pancreatic cancer

Published:2018 Issue:15 Volume:6 Page:2230-2239
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Emamzadeh Mandana¹²³⁴,Desmaële Didier⁵⁶⁷⁸⁹,Couvreur Patrick⁵⁶⁷⁸⁹,Pasparakis George¹²³⁴^ORCID

Affiliation:

1. University College London

2. School of Pharmacy

3. London WC1N 1AX

4. UK

5. Institut Galien

6. UMR 8612

7. CNRS

8. Université Paris-Sud, Université Paris-Saclay

9. Faculté de Pharmacie

Abstract

A thermoresponsive block copolymer has been developed with the capability to co-carry two drug molecules and to augment their cytotoxic properties via direct cell membrane interaction with cancer cells.

Funder

Engineering and Physical Sciences Research Council

School of Pharmacy, University College London

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2018/TB/C7TB02899G

Reference40 articles.

1. European cancer mortality predictions for the year 2014

2. Pancreatic cancer

3. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.

4. Cellular pharmacology of gemcitabine

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