Improvement effect of a next-generation probiotic <i>L. plantarum</i>-pMG36e-GLP-1 on type 2 diabetes mellitus <i>via</i> the gut–pancreas

Improvement effect of a next-generation probiotic L. plantarum-pMG36e-GLP-1 on type 2 diabetes mellitus via the gut–pancreas–liver axis

Published:2023 Issue:7 Volume:14 Page:3179-3195
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Hu Hong¹,Luo Jie²,Liu Ying³,Li Hongyu⁴,Jin Rui⁴,Li Shengjie¹,Wei Jing¹,Wei Hong⁵,Chen Tingtao¹^ORCID

Affiliation:

1. National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang 330031, P. R. China

2. School of Public Health and Key Laboratory of Preventive Medicine, Nanchang University, Nanchang 330031, P. R. China

3. Life Science Institute, Nanchang University, Nanchang 330031, P. R. China

4. School of Queen Mary, Nanchang University, Nanchang, 330031, P. R. China

5. Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, P. R. China

Abstract

A next-generation probiotic Lactobacillus plantarum-pMG36e-GLP-1 was constructed to express GLP-1 in vivo, which may affect the gut-pancreas-liver axis, thereby relieving the symptoms of HFD/STZ-induced T2DM mice and db/db mice.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO00044C

Reference67 articles.

1. Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice

2. IDF Diabetes Atlas: Estimation of Global and Regional Gestational Diabetes Mellitus Prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group’s Criteria

3. Diabetes mellitus

4. J. C.Clapham , Sixty years of drug discovery for type 2 diabetes: Where are we now? , in Methods in Molecular Biology , 2020 , Humana , New York, NY , vol. 2076

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