Tuning molecular assembly behavior to amplify the sonodynamic activity of porphyrins for efficient antibacterial therapy

Author:

Wang Yunxia1ORCID,Xu Yicheng1,Zhang Rui2,Li Jing1ORCID,Cong Yujie3,Li Ruipeng1,Wang Xiaoyu3ORCID,Shi Hu1ORCID,Wang Shaowei2,Feng Liheng14ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P.R. China

2. Shanxi Key Lab of Bone and Soft Tissue Injury Repair, Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan 030001, P.R. China

3. School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, P.R China

4. Institute for Carbon-Based Thin Film Electronics, Peking University, Shanxi (ICTFE-PKU), Taiyuan 030012, China

Abstract

A new strategy to enhance molecular sonosensitivity is disclosed via tuning molecular assembly behavior, achieving highly efficient sonodynamic therapy of septic arthritis in a rat model.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

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