Synthesis of hydrophilic caged DAG-lactones for chemical biology applications-Reference-Cited by-同舟云学术

Synthesis of hydrophilic caged DAG-lactones for chemical biology applications

Published:2020 Issue:22 Volume:18 Page:4217-4223
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kobayakawa Takuya¹²³⁴,Takano Hikaru¹²³⁴,Ishii Takahiro¹²³⁴,Tsuji Kohei¹²³⁴^ORCID,Ohashi Nami¹²³⁴,Nomura Wataru¹²³⁴^ORCID,Furuta Toshiaki⁵⁶⁷⁸⁴^ORCID,Tamamura Hirokazu¹²³⁴^ORCID

Affiliation:

1. Institute of Biomaterials and Bioengineering

2. Tokyo Medical and Dental University (TMDU)

3. Tokyo 101-0062

4. Japan

5. Department of Biomolecular Science

6. Faculty of Science

7. Toho University

8. Funabashi 274-8510

Abstract

8-Azacoumarin-4-ylmethyl-type PPGs: The synthesized caged-DAG-lactones with 8-aza-Bhc and 8-aza-Ihc groups showed the enhancement of hydrophilicity and the highest photolytic efficiency among existent caged-DAG-lactones.

Funder

Uehara Memorial Foundation

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00807A

Reference40 articles.

1. Development of photolabile protecting groups and their application to the optochemical control of cell signaling

2. Illuminating the Chemistry of Life: Design, Synthesis, and Applications of “Caged” and Related Photoresponsive Compounds

3. Highly Efficient and Ultrafast Phototriggers for cAMP and cGMP by Using Long-Wavelength UV/Vis-Activation

4. Optochemical Control of Biological Processes in Cells and Animals

5. Light-Triggered Multifunctionality at Surfaces Mediated by Photolabile Protecting Groups