Developing crosslinkers specific for epimerization domain in NRPS initiation modules to evaluate mechanism-Reference-Cited by-同舟云学术

Developing crosslinkers specific for epimerization domain in NRPS initiation modules to evaluate mechanism

Published:2022 Issue:3 Volume:3 Page:312-319
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Kim Woojoo E.¹^ORCID,Ishikawa Fumihiro²^ORCID,Re Rebecca N.¹^ORCID,Suzuki Takehiro³,Dohmae Naoshi³^ORCID,Kakeya Hideaki⁴^ORCID,Tanabe Genzoh²^ORCID,Burkart Michael D.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla CA 92093-0358, USA

2. Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan

3. Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

4. Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan

Abstract

Epimerization (E) domain mechanism in initiaion modules of NRPSs studied using pantetheine analog crosslinking probes containing sulfonyl warheads that target domain's catalytic residues (His and Glu).

Funder

National Institute of General Medical Sciences

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CB/D2CB00005A

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