Phosphorothioate anti-sense oligonucleotides: the kinetics and mechanism of the generation of the sulfurising agent from phenylacetyl disulfide (PADS)-Reference-Cited by-同舟云学术

Phosphorothioate anti-sense oligonucleotides: the kinetics and mechanism of the generation of the sulfurising agent from phenylacetyl disulfide (PADS)

Published:2016 Issue:35 Volume:14 Page:8301-8308
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Scotson James L.¹²³⁴,Andrews Benjamin I.⁵⁶⁴,Laws Andrew P.¹²³⁴,Page Michael I.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Huddersfield

3. Queensgate

4. UK

5. GSK Medicines Research Centre

6. Stevenage

Abstract

Sulfurisation of the nucleotide–phosphite using phenylacetyl disulfide (PADS) requires the generation of polysulfides by an E1_cB-type elimination to generate a ketene and acyldisulfide anion.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01531J

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