Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling

Author:

Tsionou Maria Iris1234,Knapp Caroline E.5674ORCID,Foley Calum A.1234,Munteanu Catherine R.1234,Cakebread Andrew8194,Imberti Cinzia1234ORCID,Eykyn Thomas R.1234,Young Jennifer D.1234,Paterson Brett M.10111213,Blower Philip J.1234ORCID,Ma Michelle T.1234ORCID

Affiliation:

1. King's College London

2. Division of Imaging Sciences and Biomedical Engineering

3. London SE1 7EH

4. UK

5. Department of Chemistry

6. University College London

7. London WC1H 0AJ

8. Division of Analytical and Environmental Sciences

9. London SE1 9NH

10. School of Chemistry

11. Bio21 Molecular Science and Biotechnology Institute

12. The University of Melbourne

13. Australia

Abstract

A range of macrocyclic and acyclic chelators have been reacted with the PET isotope, gallium-68, and their radiolabelling efficiencies have been compared. Structural data for complexes of HBED with Ga3+ are reported.

Funder

Guy's and St Thomas' NHS Foundation Trust

Cancer Research UK

Wellcome Trust

EPSRC

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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