A physiologically active interpenetrating collagen network that supports growth and migration of epidermal keratinocytes: zinc-polyP nanoparticles integrated into compressed collagen

Author:

Müller Werner E. G.1234ORCID,Schepler Hadrian5264,Tolba Emad1234,Wang Shunfeng1234,Ackermann Maximilian7284,Muñoz-Espí Rafael9101112ORCID,Xiao Shichu131415,Tan Rongwei161715,She Zhending161715,Neufurth Meik1234,Schröder Heinz C.123418,Wang Xiaohong1234ORCID

Affiliation:

1. ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry

2. University Medical Center of the Johannes Gutenberg University

3. 55128 Mainz

4. Germany

5. Faculty of Plastic and Aesthetic Surgery

6. 55131 Mainz

7. Institute of Functional and Clinical Anatomy

8. 55099 Mainz

9. Institute of Materials Science (ICMUV)

10. Universitat de València

11. València

12. Spain

13. Shanghai Changhai Hospital

14. Shanghai 200000

15. P. R. China

16. Shenzhen Lando Biomaterials Co., Ltd

17. Shenzhen 518107

18. NanotecMARIN GmbH

Abstract

It is demonstrated that polyphosphate, as a component in wound healing mats together with Zn2+, is essential for growth and migration of skin keratinocytes.

Funder

H2020 European Research Council

Bundesministerium für Bildung und Forschung

European Commission

European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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