Direct osteogenesis and immunomodulation dual function via sustained release of naringin from the polymer scaffold

Author:

Xiong Wei1ORCID,Yuan Lingmei2,Huang Jinyang1,Pan Bin1,Guo Ling1,Qian Guowen3,Shuai Cijun456ORCID,Zeng Zhikui78ORCID

Affiliation:

1. Jiangxi University of Chinese Medicine, Nanchang 330004, China

2. Department of ophthalmology, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China

3. School of Energy and Mechanical Engineering, Jiangxi University of Science and Technology, Nanchang 330013, China

4. Institute of Additive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China

5. State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China

6. College of Mechanical Engineering, Xinjiang University, Urumqi 830017, China

7. Department of Orthopedics and Trauma, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China

8. National Engineering Research Center for Manufacturing Technology of Traditional Chinese Medicine Solid Preparations, Jiangxi University of Chinese Medicine, Nanchang 330004, China

Abstract

In this work, the NG-MBG/PLLA scaffolds not only have a good ability to promote osteogenic differentiation of mBMSCs but also provide suitable bone immune microenvironment capabilities for bone regeneration during the inflammatory phase.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangxi Province

Guangdong Key Laboratory of Precision Equipment and Manufacturing Technology

Jiangxi University of Traditional Chinese Medicine

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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