Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications

Author:

Pereira Patricia M. R.12345,Korsak Barbara1234,Sarmento Bruno67849,Schneider Rudolf J.101112,Fernandes Rosa513141516,Tomé João P. C.123417

Affiliation:

1. QOPNA and Department of Chemistry

2. University of Aveiro

3. 3810-193 Aveiro

4. Portugal

5. Laboratory of Pharmacology and Experimental Therapeutics

6. INEB – Instituto de Engenharia Biomédica

7. Biocarrier Group

8. 4150-180 Porto

9. CESPU

10. BAM Federal Institute for Materials Research and Testing

11. D-12205 Berlin

12. Germany

13. IBILI – Institute for Biomedical Imaging and Life Sciences

14. Faculty of Medicine

15. University of Coimbra

16. 3000-548 Coimbra

17. Department of Organic and Macromolecular Chemistry

Abstract

Targeting photosensitizers to cancer cells by conjugating them with specific antibodies, able to recognize and bind to tumor-associated antigens, is today one of the most attractive strategies in photodynamic therapy (PDT).

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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