Impact of the zinc complexation of polytopic polyaza ligands on the interaction with double and single stranded DNA/RNA and antimicrobial activity-Reference-Cited by-同舟云学术

Impact of the zinc complexation of polytopic polyaza ligands on the interaction with double and single stranded DNA/RNA and antimicrobial activity

Published:2023 Issue:17 Volume:52 Page:5478-5485
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

González-García Jorge¹^ORCID,Galiana Carolina²,Dea-Ayuela M. Auxiliadora²,Radić Stojković Marijana³,López-Molina Sonia¹^ORCID,Galiana-Roselló Cristina¹,Blasco Salvador¹,Piantanida Ivo³^ORCID,García-España Enrique¹^ORCID

Affiliation:

1. Institute of Molecular Science, University of Valencia, Department of Inorganic Chemistry, 46009, Paterna, Spain

2. Department of Pharmacy, CEU Cardenal Herrera University, Ramón y Cajal s/n, 46115 Alfara del Patriarca, Spain

3. Division of Organic Chemistry & Biochemistry, Ruđer Bošković Institute, P. O. Box 180, 10002 Zagreb, Croatia

Abstract

Two polytopic ligands and their zinc complexes show a high interaction with DNA/RNA and different recognition abilities of the nucleic acids depending on the base composition. The antimicrobial activity is higher for the free ligands.

Funder

Generalitat Valenciana

European Cooperation in Science and Technology

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/DT/D3DT00395G

Reference40 articles.

1. Metallodrugs in Medicinal Inorganic Chemistry

2. Noble metals in medicine: Latest advances

3. Developing new metal-based therapeutics: challenges and opportunities

4. Metallodrugs are unique: opportunities and challenges of discovery and development

5. Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles