(<i>R</i>,<i>S</i>)-Equol 7-β-D-glucuronide, but not other circulating isoflavone metabolites, modulates migration and tubulogenesis in human aortic endothelial cells targeting the VEGF pathway-Reference-Cited by-同舟云学术

(R,S)-Equol 7-β-D-glucuronide, but not other circulating isoflavone metabolites, modulates migration and tubulogenesis in human aortic endothelial cells targeting the VEGF pathway

Published:2024 Issue: Volume: Page:
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Giménez-Bastida Juan Antonio¹,Ávila-Gálvez María Ángeles¹²,Martínez-López Alicia³⁴,García-Moreno Diana³⁴,Espín Juan Carlos¹^ORCID,González-Sarrías Antonio¹^ORCID

Affiliation:

1. Laboratory of Food & Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, Murcia, Spain

2. NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, Lisboa, Portugal

3. Center for Biomedical Research in Rare Diseases Network (CIBERER), Carlos III Health Institute, 28029, Madrid, Spain

4. Biomedical Research Institute of Murcia (IMIB)-Pascual Parrilla, 30120, Murcia, Spain

Abstract

Dietary isoflavones, genistein and daidzein, and their derived microbial metabolites, including equol and equol 7-β-d-glucuronide, target the VEGFR2 pathway and modulate processes related to angiogenesis.

Funder

European Commission

Agencia Estatal de Investigación

European Regional Development Fund

Fundación Séneca

HORIZON EUROPE Marie Sklodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D3FO03946C

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