Endothelial cell polarization and orientation to flow in a novel microfluidic multimodal shear stress generator-Reference-Cited by-同舟云学术

Endothelial cell polarization and orientation to flow in a novel microfluidic multimodal shear stress generator

Published:2020 Issue:23 Volume:20 Page:4373-4390
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Sonmez Utku M.¹²³⁴⁵^ORCID,Cheng Ya-Wen⁶⁷⁸³⁴^ORCID,Watkins Simon C.⁹¹⁰⁸³⁴,Roman Beth L.⁵¹¹⁸³⁴^ORCID,Davidson Lance A.⁶⁷⁸³⁴^ORCID

Affiliation:

1. Department of Mechanical Engineering

2. Carnegie Mellon University

3. Pittsburgh

4. USA

5. Department of Human Genetics

6. Department of Bioengineering

7. Swanson School of Engineering

8. University of Pittsburgh

9. Department of Cell Biology

10. School of Medicine

11. Graduate School of Public Health

Abstract

Endothelial cell polarization and orientation analysis using a novel microfluidic device that can simultaneously generate multiple levels of shear stress and shear stress gradients for systematic mechanobiology studies under flow.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/LC/D0LC00738B

Reference69 articles.

1. Mechanotransduction in embryonic vascular development

2. The nucleus of endothelial cell as a sensor of blood flow direction

3. PAR ‐3 controls endothelial planar polarity and vascular inflammation under laminar flow

4. Cell Migration: Integrating Signals from Front to Back

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