Cortical spheroids display oscillatory network dynamics-Reference-Cited by-同舟云学术

Cortical spheroids display oscillatory network dynamics

Published:2021 Issue:23 Volume:21 Page:4586-4595
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Sevetson Jessica L.¹²³^ORCID,Theyel Brian¹²⁴,Hoffman-Kim Diane¹²³⁵^ORCID

Affiliation:

1. Department of Neuroscience, Brown University, Providence, RI 02906, USA

2. Robert J and Nancy D Carney Institute for Brain Science, Brown University, Providence, RI 02906, USA

3. Center for the Alternatives to Animals in Testing, Brown University, Providence, RI 02906, USA

4. Department of Psychiatry, Brown University, Providence, RI 02906, USA

5. Center for Biomedical Engineering, Brown University, Providence, RI 02906, USA

Abstract

3-D spheroid cultures contain networks that develop by 9 days and develop increasingly complex network activity patterns as they mature. We demonstrate, for the first time, that spheroids exhibit network activity similar to in vivo network events.

Funder

Office of Naval Research

National Institute of Environmental Health Sciences

Brown University

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D1LC00737H

Reference37 articles.

1. Cerebral organoids model human brain development and microcephaly

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3. Three-Dimensional Neural Spheroid Culture: AnIn VitroModel for Cortical Studies

4. Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

5. Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

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