Predictive recognition of native proteins by cucurbit[7]uril in a complex mixture

Author:

Li Wei1234,Bockus Andrew T.1234,Vinciguerra Brittany5674,Isaacs Lyle5674,Urbach Adam R.1234

Affiliation:

1. Department of Chemistry

2. Trinity University

3. San Antonio

4. USA

5. Department of Chemistry and Biochemistry

6. University of Maryland

7. College Park

Abstract

The recognition of human growth hormone (hGH) by the synthetic host molecule cucurbit[7]uril (Q7) was predicted on the basis of its N-terminal phenylalanine. A resin presenting Q7 groups was prepared and shown to recognize hGH and insulin in the context of human serum.

Funder

Camille and Henry Dreyfus Foundation

U.S. Department of Energy

Division of Chemistry

University of Maryland

Welch Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Reference41 articles.

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2. G. L. Patrick , An Introduction to Medicinal Chemistry, Oxford University Press, New York, NY, 5th edn, 2005

3. A Decade of Bioorthogonal Chemistry

4. Peptide and Protein Recognition by Designed Molecules

5. Methods in Enzymology, ed. B. R. Richard and M. P. Deutscher, Academic Press, San Diego, USA, 2009, vol. 463

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