Cascade dearomative [4 + 2] cycloaddition of indoles with <i>in situ</i> generated <i>ortho</i>-quinone methides: practical access to divergent indoline-fused polycycles-Reference-Cited by-同舟云学术

Cascade dearomative [4 + 2] cycloaddition of indoles with in situ generated ortho-quinone methides: practical access to divergent indoline-fused polycycles

Published:2022 Issue:9 Volume:24 Page:3772-3777
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Dong Pei-Zhen¹,Qiu Bin¹,An Xiao-De¹^ORCID,Xiao Jian¹²^ORCID

Affiliation:

1. College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China

2. College of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China

Abstract

A rationally designed cascade dearomative [4 + 2] cycloaddition of indoles with in situ generated o-QM has been developed to assemble indoline-fused polycycles divergently with high yields and excellent diastereoselectivity in one step.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/GC/D2GC00387B

Reference60 articles.

1. Synthesis of Polyquinane Natural Products: An Update

2. Polycyclic Furanobutenolide-Derived Cembranoid and Norcembranoid Natural Products: Biosynthetic Connections and Synthetic Efforts

3. Simple indole alkaloids and those with a non-rearranged monoterpenoid unit