Non-covalent albumin-binding ligands for extending the circulating half-life of small biotherapeutics

Author:

Zorzi Alessandro12345ORCID,Linciano Sara6789ORCID,Angelini Alessandro678910ORCID

Affiliation:

1. Institute of Chemical Sciences and Engineering

2. School of Basic Sciences

3. Ecole Polytechnique Fédérale de Lausanne (EPFL)

4. Lausanne CH-1015

5. Switzerland

6. Department of Molecular Sciences and Nanosystems

7. Ca' Foscari University of Venice

8. Venezia Mestre 30172

9. Italy

10. European Centre for Living Technologies (ECLT)

Abstract

This review provides a detailed examination and comparison of the diverse non-covalent albumin-binding ligands developed until now to extend the half-life of different small biotherapeutics.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

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