Synthesis and biological evaluation of benzocyclooctene-based and indene-based anticancer agents that function as inhibitors of tubulin polymerization-Reference-Cited by-同舟云学术

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Synthesis and biological evaluation of benzocyclooctene-based and indene-based anticancer agents that function as inhibitors of tubulin polymerization

Published:2016 Issue:12 Volume:7 Page:2418-2427
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Herdman Christine A.¹²³⁴,Strecker Tracy E.¹²³⁴,Tanpure Rajendra P.¹²³⁴,Chen Zhi¹²³⁴,Winters Alex⁵⁶⁷⁸⁴,Gerberich Jeni⁵⁶⁷⁸⁴,Liu Li⁵⁶⁷⁸⁴,Hamel Ernest⁹¹⁰¹¹¹²¹³,Mason Ralph P.⁵⁶⁷⁸⁴,Chaplin David J.¹²³⁴¹⁴,Trawick Mary Lynn¹²³⁴,Pinney Kevin G.¹²³⁴

Affiliation:

1. Department of Chemistry and Biochemistry

2. Baylor University

3. Waco

4. USA

5. Prognostic Imaging Research Laboratory

6. Department of Radiology

7. The University of Texas Southwestern Medical Center

8. Dallas

9. Screening Technologies Branch

10. Developmental Therapeutics Program

11. Division of Cancer Treatment and Diagnosis

12. National Cancer Institute

13. Frederick National Laboratory for Cancer Research

14. Mateon Therapeutics, Inc.

Abstract

Synthesis of benzocyclooctene and indene analogues inspired by colchicine and combretastatin A-4.

Funder

National Cancer Institute

Cancer Prevention and Research Institute of Texas

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00459H

Reference77 articles.

1. Taxol stabilizes microtubules in mouse fibroblast cells.

2. Taxol assembles tubulin in the absence of exogenous guanosine 5'-triphosphate or microtubule-associated proteins

3. Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

4. A Note on the Alkaloids of Vinca rosea Linn. (Catharanthus roseus G. Don.) II.**Lilly Research Laboratories and Organic Chemical Development, Eli Lilly and Co., Indianapolis, Ind.

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