Tetrazine- and trans-cyclooctene-functionalised polypept(o)ides for fast bioorthogonal tetrazine ligation

Author:

Johann Kerstin1234,Svatunek Dennis5678ORCID,Seidl Christine1234,Rizzelli Silvia1234,Bauer Tobias A.1234,Braun Lydia1234,Koynov Kaloian934ORCID,Mikula Hannes5678ORCID,Barz Matthias1234ORCID

Affiliation:

1. Department of Chemistry

2. Johannes Gutenberg University Mainz

3. 55128 Mainz

4. Germany

5. Institute of Applied Synthetic Chemistry

6. Technische Universität Wien

7. 1060 Vienna

8. Austria

9. Max Planck Institute for Polymer Research

Abstract

Tetrazine- and trans-cyclooctene-functionalised polypeptides and polypetoids were prepared by ring-opening polymerisation of N-carboxyanhydrides using the respective functional initiators and shown to react in fast bioorthogonal tetrazine ligations.

Funder

H2020 Health

Deutsche Forschungsgemeinschaft

Johannes Gutenberg-Universität Mainz

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

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