Cells function as a ternary logic gate to decide migration direction under integrated chemical and fluidic cues-Reference-Cited by-同舟云学术

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Cells function as a ternary logic gate to decide migration direction under integrated chemical and fluidic cues

Published:2023 Issue:4 Volume:23 Page:631-644
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Moon Hye-ran¹^ORCID,Saha Soutick²,Mugler Andrew²³⁴^ORCID,Han Bumsoo¹³⁵^ORCID

Affiliation:

1. School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA

2. Department of Physics and Astronomy, Purdue University, West Lafayette, IN, USA

3. Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, USA

4. Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA 15260, USA

5. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA

Abstract

A reverse-engineered systems biology framework of directed cell migration in which cells function as a ternary logic gate to decode entangled chemical and fluidic cues to determine migration direction.

Funder

National Institutes of Health

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/LC/D2LC00807F

Reference87 articles.

1. Dendritic cell migration in health and disease

2. Immune cell migration in inflammation: present and future therapeutic targets

3. Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis

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