Evolutionary identification of affinity peptides for the detection of sepsis biomarker procalcitonin-Reference-Cited by-同舟云学术

Evolutionary identification of affinity peptides for the detection of sepsis biomarker procalcitonin

Published:2015 Issue:110 Volume:5 Page:90531-90533
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Park J. P.¹²³⁴,Park C. Y.¹²³⁴,Park A. Y.¹²³⁴,Ryu M. Y.¹²³⁴

Affiliation:

1. Department of Pharmaceutical Engineering

2. Daegu Haany University

3. Gyeongsan 38610

4. Republic of Korea

Abstract

We demonstrate for the first time the use of phage display for the discovery of unique peptide motifs which are capable of binding to procalcitonin. The best peptide specific for procalcitonin was found to be 1.9 ± 0.001 nanomolar affinity.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA20260D

Reference18 articles.

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4. Procalcitonin as a rapid diagnostic biomarker to differentiate between culture-negative bacterial sepsis and systemic inflammatory response syndrome: A prospective, observational, cohort study

5. Rapid real-time detection of procalcitonin using a microcontact imprinted surface plasmon resonance biosensor

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