Total synthesis of (±)-(1β,4β,4aβ,8aα)-4,8a-dimethyl-octahydro-naphthalene-1,4a(2H)-diol-Reference-Cited by-同舟云学术

Total synthesis of (±)-(1β,4β,4aβ,8aα)-4,8a-dimethyl-octahydro-naphthalene-1,4a(2H)-diol

Published:2018 Issue:10 Volume:5 Page:1719-1723
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Liu Qingyin¹²³⁴⁵,Han Li¹²³⁴⁵^ORCID,Qin Bing¹²³⁴⁵,Mu Yu¹²³⁴⁵,Guan Peipei¹²³⁴⁵,Wang Songyao⁶⁷⁵,Huang Xueshi¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Microbial Pharmaceuticals

2. College of Life and Health Sciences

3. Northeastern University

4. Shenyang 110819

5. P. R. China

6. Benxi Senior Middle School

7. Benxi 117000

Abstract

The first total synthesis of (±)-(1β,4β,4aβ,8aα)-4,8a-dimethylocta-hydronaphthalene-1,4a(2H)-diol (1), a degraded sesquiterpene isolated from a fermentation broth of Streptomyces albolongus, has been achieved via three different synthetic approaches (13–15 steps) starting from racemic Wieland–Miescher ketone (2).

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/QO/C8QO00225H

Reference23 articles.

1. Atypical Clinical Presentation of a Newer Generation Anti-Fungal Drug-Resistant Fusarium Infection After a Modified Multi-Visceral Transplant

2. Microbial drug discovery: 80 years of progress

3. Acquired Multidrug Antifungal Resistance in Candida lusitaniae during Therapy