Semisynthesis and antitumor activity of endertiin B and related triterpenoids from <i>Ganoderma lucidum</i>-Reference-Cited by-同舟云学术

Semisynthesis and antitumor activity of endertiin B and related triterpenoids from Ganoderma lucidum

Published:2024 Issue:24 Volume:22 Page:4978-4986
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Liu Yu¹²,Wen Hong-Kai¹²,Xu Rui-Xuan¹²,Liu Chang¹²,Li Xiao-Han¹²,Qin Xiang-Dong²,Zhao You-Xing³^ORCID,Jia Yan-Xing⁴,Luo Dou-Qiang¹²^ORCID

Affiliation:

1. College of Life Science, Hebei University, Baoding, China

2. Hebei Innovation Center for Bioengineering and Biotechnology, Hebei University, Baoding, China

3. Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, People's Republic of China

4. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, and Chemical Biology Center, Peking University, Beijing, China

Abstract

Four natural products of Ganoderma lucidum triterpenoids were semi-synthesized for the first time and the active compound endertiin B was demonstrated to play an anti-breast cancer role through the PI3K-AKT pathway.

Funder

Program for Changjiang Scholars and Innovative Research Team in University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00641K

Reference50 articles.

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2. Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection

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5. Lanostanoid Triterpenes from Ganoderma lucidum