A highly specific aptamer for the SARS-CoV-2 spike protein from the authentic strain

Author:

Khrenova Maria G.12ORCID,Nikiforova Lyudmila1,Grabovenko Fedor1,Orlova Nadezhda3ORCID,Sinegubova Maria1,Kolesov Denis3ORCID,Zavyalova Elena1ORCID,Subach Maksim F.1ORCID,Polyakov Igor V.1ORCID,Zatzepin Timofei1ORCID,Zvereva Maria1ORCID

Affiliation:

1. Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia

2. Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences, Moscow 119071, Russia

3. Laboratory of Mammalian Cell Bioengineering, Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences, Moscow 117312, Russia

Abstract

MEZ is a 31-mer aptamer that is highly specific to the RBD from the SARS-CoV-2 Wuhan-Hu-1 strain with Kd = 6.5 nM.

Funder

Poccийcкий Фoнд Фyндaмeнтaльных Иccлeдoвaний

Publisher

Royal Society of Chemistry (RSC)

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