A highly specific aptamer for the SARS-CoV-2 spike protein from the authentic strain-Reference-Cited by-同舟云学术

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A highly specific aptamer for the SARS-CoV-2 spike protein from the authentic strain

Published:2024 Issue:29 Volume:22 Page:5936-5947
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Khrenova Maria G.¹²^ORCID,Nikiforova Lyudmila¹,Grabovenko Fedor¹,Orlova Nadezhda³^ORCID,Sinegubova Maria¹,Kolesov Denis³^ORCID,Zavyalova Elena¹^ORCID,Subach Maksim F.¹^ORCID,Polyakov Igor V.¹^ORCID,Zatzepin Timofei¹^ORCID,Zvereva Maria¹^ORCID

Affiliation:

1. Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia

2. Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences, Moscow 119071, Russia

3. Laboratory of Mammalian Cell Bioengineering, Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences, Moscow 117312, Russia

Abstract

MEZ is a 31-mer aptamer that is highly specific to the RBD from the SARS-CoV-2 Wuhan-Hu-1 strain with Kd = 6.5 nM.

Funder

Poccийcкий Фoнд Фyндaмeнтaльных Иccлeдoвaний

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00645C

Reference39 articles.

1. Drugs for COVID-19: An Update

2. New COVID drugs face delays as trials grow more difficult

3. Potential therapeutic options for COVID-19: an update on current evidence

4. Improving the early identification of COVID-19 pneumonia: a narrative review

5. Fast and noninvasive electronic nose for sniffing out COVID-19 based on exhaled breath-print recognition

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