Unexpected photoactivation pathways in a folate-receptor-targeted trans-diazido Pt(iv) anticancer pro-drug-Reference-Cited by-同舟云学术

Unexpected photoactivation pathways in a folate-receptor-targeted trans-diazido Pt(iv) anticancer pro-drug

Published:2020 Issue:34 Volume:49 Page:11828-11834
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Gandioso Albert¹²³⁴⁵,Rovira Anna¹²³⁴⁵,Shi Huayun⁶⁷⁸⁹,Sadler Peter J.⁶⁷⁸⁹^ORCID,Marchán Vicente¹²³⁴⁵^ORCID

Affiliation:

1. Departament de Química Inorgànica i Orgànica

2. Secció de Química Orgànica

3. IBUB

4. Universitat de Barcelona

5. E-08028 Barcelona

6. Department of Chemistry

7. University of Warwick

8. Coventry CV4 7AL

9. UK

Abstract

Photoactivation of a conjugate between a photoactive trans-diazido Pt(iv) pro-drug and folic acid generates different cytotoxic species, including Pt(ii) photoproducts and pterin derivatives.

Funder

University of Warwick

Universitat de Barcelona

Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya

Engineering and Physical Sciences Research Council

Secretaría de Estado de Investigación, Desarrollo e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/DT/D0DT02577A

Reference44 articles.

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