Raman spectroscopic screening of high and low molecular weight fractions of human serum

Author:

Parachalil Drishya Rajan12345ORCID,Bruno Clément678910,Bonnier Franck678910,Blasco Hélène111213106,Chourpa Igor678910ORCID,McIntyre Jennifer1234,Byrne Hugh J.1234ORCID

Affiliation:

1. FOCAS Research Institute

2. Technological University Dublin

3. Dublin 8

4. Ireland

5. School of Physics and Optometric & Clinical Sciences

6. Université de Tours

7. UFR sciences pharmaceutiques

8. EA 6295 Nanomédicaments et Nanosondes

9. 37200 Tours

10. France

11. CHRU de Tours

12. Laboratoire de Biochimie et Biologie Moléculaire

13. Tours

Abstract

This study explores the suitability of Raman spectroscopy as a bioanalytical tool, when coupled with ultra-filtration and multivariate analysis, to detect imbalances in both high molecular weight and low molecular weight fractions of the same samples of human patient serum, in the native liquid form.

Funder

Dublin Institute of Technology

Science Foundation Ireland

Irish Research Council

Campus France

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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