Ensemble clustering of phosphoproteomic data identifies differences in protein interactions and cell–cell junction integrity of HER2-overexpressing cells
Author:
Affiliation:
1. Department of Biomedical Engineering
2. Washington University in St. Louis
3. St. Louis
4. USA
5. Center for Biological Systems Engineering
Abstract
Overexpression of HER2, a receptor tyrosine kinase of the ERBB family, is related to increased cancer progression and aggressiveness.
Publisher
Oxford University Press (OUP)
Subject
Biochemistry,Biophysics
Link
http://pubs.rsc.org/en/content/articlepdf/2017/IB/C7IB00054E
Reference33 articles.
1. The HER-2/neu Gene and Protein in Breast Cancer 2003: Biomarker and Target of Therapy
2. Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene
3. NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer
4. Effects of HER2 overexpression on cell signaling networks governing proliferation and migration
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