Effect of D168V mutation in NS3/4A HCV protease on susceptibilities of faldaprevir and danoprevir-Reference-Cited by-同舟云学术

Effect of D168V mutation in NS3/4A HCV protease on susceptibilities of faldaprevir and danoprevir

Author:

Meeprasert Arthitaya¹²³⁴⁵,Hannongbua Supot⁶⁷⁸⁹⁴,Kungwan Nawee⁷⁸¹⁰¹¹⁵,Rungrotmongkol Thanyada¹²³⁴⁵

Affiliation:

1. Structural and Computational Biology Research Group

2. Department of Biochemistry

3. Faculty of Science Chulalongkorn University

4. Bangkok 10330

5. Thailand

6. Computational Chemistry Unit Cell

7. Department of Chemistry

8. Faculty of Science

9. Chulalongkorn University

10. Chiang Mai University

11. Chiang Mai 50200

Abstract

Disrupted hydrogen bonding network in the extended S2 subsite lead to faldaprevir and danoprevir resistances.

Funder

Thailand Research Fund

National Science and Technology Development Agency

Chulalongkorn University

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

Reference47 articles.

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