Protonophoric and mitochondrial uncoupling activity of aryl-carbamate substituted fatty acids

Author:

MacDermott-Opeskin Hugo1ORCID,Clarke Callum2,Wu Xin34ORCID,Roseblade Ariane2,York Edward2,Pacchini Ethan2,Roy Ritik2,Cranfield Charles5ORCID,Gale Philip A.36ORCID,O'Mara Megan L.17ORCID,Murray Michael8,Rawling Tristan2ORCID

Affiliation:

1. Research School of Chemistry, College of Science, The Australian National University, Canberra, ACT, 0200, Australia

2. School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, 2007, Australia

3. School of Chemistry, The University of Sydney, NSW, 2006, Australia

4. School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia

5. School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, 2007, Australia

6. The University of Sydney Nano Institute (SydneyNano), The University of Sydney, NSW, 2006, Australia

7. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia

8. Discipline of Pharmacology, School of Medical Sciences, The University of Sydney, NSW 2006, Australia

Abstract

Aryl-carbamate substituted fatty acids are protonophores that uncouple mitochondrial oxidative phosphorylation. The proton transport cycle requires self-assembly into membrane permeable dimers. The findings demonstrate the anion transport capability of the carbamate group.

Funder

Australian Research Council

National Health and Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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