Reactivity <i>vs.</i> selectivity of quinone methides: synthesis of pharmaceutically important molecules, toxicity and biological applications-Reference-Cited by-同舟云学术

Reactivity vs. selectivity of quinone methides: synthesis of pharmaceutically important molecules, toxicity and biological applications

Published:2022 Issue:42 Volume:58 Page:6160-6175
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ali Kasim¹²,Mishra Prajjval¹,Kumar Awnish¹,Reddy Damodara N¹²,Chowdhury Sushobhan¹,Panda Gautam¹²^ORCID

Affiliation:

1. Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Sector 10, Lucknow 226031, UP, India

2. Academy of Scientific & Industrial Research (AcSIR), Ghaziabad, Uttar Pradesh-201 002, India

Abstract

The synthetic routes, structure–reactivity relationships and synthetic applications of quinone methides, along with possible chemical manifestations leading to their toxicity in biological systems, are discussed.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC00838F

Reference143 articles.

1. S. E.Rokita , Quinone Methide , Wiley , New York , 2009

2. Substituents on Quinone Methides Strongly Modulate Formation and Stability of Their Nucleophilic Adducts

3. BINOL−Amino Acid Conjugates as Triggerable Carriers of DNA-Targeted Potent Photocytotoxic Agents

4. Quinone Methides Tethered to Naphthalene Diimides as Selective G-Quadruplex Alkylating Agents

5. Dynamic Cross-Linking Is Retained in Duplex DNA after Multiple Exchange of Strands

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Decaging-to-labeling: Development and investigation of quinone methide warhead for protein labeling;Bioorganic Chemistry;2024-02

2. Organocatalytic Chemoselective C4‐Benzylation of 5‐Aminopyrazoles;Asian Journal of Organic Chemistry;2024-01-09

3. An esterase-cleavable persulfide donor with no electrophilic byproducts and a fluorescence reporter;Chemical Communications;2024

4. Transition‐Metal‐Free Multicomponent Approach to the Regioselective Synthesis of Highly Substituted N ‐Alkylpyrazoles;Chemistry – An Asian Journal;2023-01-13

5. Regio- and diastereoselective synthesis of diverse spirocyclic indenes by cyclization with indene-dienes as two carbon building blocks;Organic & Biomolecular Chemistry;2023