CRISPR/Cas12a-mediated gold nanoparticle aggregation for colorimetric detection of SARS-CoV-2-Reference-Cited by-同舟云学术

CRISPR/Cas12a-mediated gold nanoparticle aggregation for colorimetric detection of SARS-CoV-2

Published:2021 Issue:56 Volume:57 Page:6871-6874
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Cao Yiren¹²³⁴,Wu Jinjun¹²³⁴^ORCID,Pang Bo¹²³⁴^ORCID,Zhang Hongquan¹²³⁴^ORCID,Le X. Chris¹²³⁴^ORCID

Affiliation:

1. Department of Laboratory Medicine and Pathology

2. University of Alberta

3. Edmonton

4. Canada

Abstract

The trans-cleavage activity of the target-activated CRISPR/Cas12a liberated an RNA crosslinker from a molecular transducer, which facilitated the assembly of gold nanoparticles.

Funder

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Social Sciences and Humanities Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC02546E

Reference24 articles.

1. SHERLOCK: nucleic acid detection with CRISPR nucleases

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4. Functional DNA Regulated CRISPR-Cas12a Sensors for Point-of-Care Diagnostics of Non-Nucleic-Acid Targets

5. CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules

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