An in vitro selective inhibitory effect of silver(i) aminoacidates against bacteria and intestinal cell lines and elucidation of the mechanism of action by means of DNA binding properties, DNA cleavage and cell cycle arrest-Reference-Cited by-同舟云学术

An in vitro selective inhibitory effect of silver(i) aminoacidates against bacteria and intestinal cell lines and elucidation of the mechanism of action by means of DNA binding properties, DNA cleavage and cell cycle arrest

Published:2021 Issue:3 Volume:50 Page:936-953
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Rendošová Michaela¹²³⁴⁵,Gyepes Róbert¹²⁶⁷⁸^ORCID,Maruščáková Ivana Cingeľová⁹¹⁰¹¹⁵,Mudroňová Dagmar⁹¹⁰¹¹⁵,Sabolová Danica¹²²³⁴⁵,Kello Martin¹³¹⁴³¹⁵⁵,Vilková Mária¹⁶²³⁴⁵,Almáši Miroslav¹²³⁴⁵^ORCID,Huntošová Veronika¹⁷¹⁸³⁴⁵,Zemek Ondřej¹²⁶⁷⁸,Vargová Zuzana¹²³⁴⁵^ORCID

Affiliation:

1. Department of Inorganic Chemistry

2. Faculty of Science

3. P. J. Šafárik University

4. 041 54 Košice

5. Slovak Republic

6. Charles University

7. 128 00 Prague

8. Czech Republic

9. Department of Microbiology and Immunology

10. University of Veterinary Medicine and Pharmacy

11. 041 81 Košice

12. Department of Biochemistry

13. Department of Pharmacology

14. Faculty of Medicine

15. 040 11 Košice

16. NMR Laboratory

17. Center for Interdisciplinary Biosciences

18. Technology and Innovation Park

Abstract

Novel silver(i) aminoacidate complexes {[Ag(HVal)(H₂O)(NO₃)]}_n (AgVal) and {[Ag₃(HAsp)₂(NO₃)]}n·nH₂O (AgAsp) were prepared, investigated, fully characterized and their antibacterial, anticancer and DNA cleavage activities were evaluated.