A novel series of phenolic temozolomide (TMZ) esters with 4 to 5-fold increased potency, compared to TMZ, against glioma cells irrespective of MGMT expression-Reference-Cited by-同舟云学术

A novel series of phenolic temozolomide (TMZ) esters with 4 to 5-fold increased potency, compared to TMZ, against glioma cells irrespective of MGMT expression

Published:2020 Issue:30 Volume:10 Page:17561-17570
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Shervington Leroy¹²³⁴^ORCID,Ingham Oliver¹²³⁴,Shervington Amal¹²³⁴

Affiliation:

1. Faculty of Pharmacy and Biomedical Science

2. The University of Central Lancashire

3. Preston

4. UK

Abstract

The standard of care treatment for patients diagnosed with glioblastoma multiforme (GBM) is temozolomide (TMZ).

Funder

University of Central Lancashire

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA02686G

Reference27 articles.

1. CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010

2. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

3. Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

4. Epidemiologic and Molecular Prognostic Review of Glioblastoma

5. Temozolomide, a Novel Alkylating Agent with Activity in the Central Nervous System, May Improve the Treatment of Advanced Metastatic Melanoma

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3. Investigating the Stability of Six Phenolic TMZ Ester Analogues, Incubated in the Presence of Porcine Liver Esterase and Monitored by HPLC;Molecules;2022-05-05