Synthesis, molecular docking and DFT studies on biologically active 1,4-disubstituted-1,2,3-triazole-semicarbazone hybrid molecules-Reference-Cited by-同舟云学术

Synthesis, molecular docking and DFT studies on biologically active 1,4-disubstituted-1,2,3-triazole-semicarbazone hybrid molecules

Published:2019 Issue:21 Volume:43 Page:8052-8058
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Naveen Naveen¹²³⁴,Tittal Ram Kumar¹²³⁴^ORCID,Yadav Pinki¹⁵⁶⁴,Lal Kashmiri¹⁵⁶⁴^ORCID,D. Ghule Vikas¹²³⁴^ORCID,Kumar Ashwani⁷⁸⁶⁴

Affiliation:

1. Department of Chemistry

2. National Institute of Technology

3. Kurukshetra

4. India

5. Guru Jambheshwar University of Science and Technology

6. Hisar

7. Department of Pharmaceutical Sciences

8. Guru Jambheshwar University of Science & Technology

Abstract

Biologically active semicarbazone-triazole hybrid molecules designed and synthesized from semicarbazone linked with a terminal alkyne and aromatic azidesviaCu(i)-catalyzed cycloaddition reaction. The synthesized compounds exhibited potent antibacterial activities against the tested bacterial strains. Computational results are in good agreement with thein vitroantimicrobial results.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/NJ/C9NJ00473D

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