A new synthetic protectin D1 analog 3-oxa-PD1n-3 DPA reduces neuropathic pain and chronic itch in mice-Reference-Cited by-同舟云学术

A new synthetic protectin D1 analog 3-oxa-PD1n-3 DPA reduces neuropathic pain and chronic itch in mice

Published:2021 Issue:12 Volume:19 Page:2744-2752
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Nesman Jannicke Irina¹²³⁴⁵,Chen Ouyang⁶⁷⁸⁹¹⁰^ORCID,Luo Xin⁶⁷⁸⁹¹⁰^ORCID,Ji Ru-Rong⁶⁷⁸⁹¹⁰^ORCID,Serhan Charles N.¹¹⁷¹²¹³¹⁴^ORCID,Hansen Trond Vidar¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmacy

2. Section for Pharmaceutical Chemistry

3. University of Oslo

4. N-0316 Oslo

5. Norway

6. Center for Translational Pain Medicine

7. Department of Anesthesiology

8. Duke University Medical Center

9. Durham

10. USA

11. Center for Experimental Therapeutics and Reperfusion Injury

12. Perioperative and Pain Medicine

13. Hale Building for Transformative Medicine

14. Brigham and Women's Hospital and Harvard Medical School

Abstract

The novel protectin D1 analog 3-oxa-PD1_{n-3 DPA} was synthesized. Nanogram amounts of this analog reduces neuropathic pain and chronic itch, and shows analgesic action in a mouse model of diabetic neuropathy.

Funder

Norges Forskningsråd

Duke University

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D0OB02136A

Reference69 articles.

1. Cellular and Molecular Mechanisms of Pain