Huperzine alkaloids: forty years of total syntheses-Reference-Cited by-同舟云学术

Huperzine alkaloids: forty years of total syntheses

Published:2024 Issue:1 Volume:41 Page:59-84
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Cheng Bichu¹²^ORCID,Song Lili¹,Chen Fener¹³²^ORCID

Affiliation:

1. Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China

2. School of Science, Green Pharmaceutical Engineering Research Center, Harbin Institute of Technology, Shenzhen 518055, China

3. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China

Abstract

This review discusses the synthetic chemistry of huperzine A, a potent inhibitor of acetylcholine esterase (AChE), followed by the advancements in other alkaloids of the family. The analogs and medicinal chemistry of huperzines are summarized.

Funder

Shenzhen Fundamental Research Program

Shenzhen Peacock Plan

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NP/D3NP00029J

Reference127 articles.

1. Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications

2. Alzheimer's disease: Targeting the Cholinergic System

3. The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity

4. Biosynthesis of lycopodine: incorporation of acetate via an intermediate with C2v symmetry

5. The Lycopodium alkaloids

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Identification of O-arylated huperzinines as novel cholinergic anti-inflammatory pathway agonists against gout arthritis;Bioorganic Chemistry;2024-11

2. Carbonic anhydrase-like enzymes in the formation of Lycopodium alkaloid;Chinese Journal of Natural Medicines;2024-03