Cell-specific activation of gemcitabine by endogenous H2S stimulation and tracking through simultaneous fluorescence turn-on

Author:

Maiti Mrinmoy1,Yoon Shin A2,Cha Yujin2,Athul K. K.3,Bhuniya Sankarprasad3ORCID,Lee Min Hee2ORCID

Affiliation:

1. Department of Science, School of Engineering, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India

2. Department of Chemistry, Sookmyung Women's University, Seoul 04310, Korea

3. Centre for Interdisciplinary Science, JIS Institute of Advanced Studies and Research, JIS University, Salt Lake, Kolkata, 700091, India

Abstract

The endogenous H2S stimulated theranostic H2S-Gem was developed for selectively ending the progression of cancer via activation of chemotherapeutic gemcitabine, which tracks theranostic events and provides anticancer efficacy against cancer cells.

Funder

National Research Foundation of Korea

Science and Engineering Research Board

Council of Scientific and Industrial Research, India

Department of Science and Technology, Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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