Chiral N-triflylphosphoramide-catalyzed asymmetric hydroamination of unactivated alkenes: a hetero-ene reaction mechanism

Author:

Wang Na123,Fan Li-Wen3,Zhang Jin3,Gu Qiang-Shuai4ORCID,Lin Jin-Shun3,Chen Guo-Qiang1,Liu Xin-Yuan3ORCID,Yu Peiyuan3ORCID

Affiliation:

1. College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518071, China

2. College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China

3. Department of Chemistry and Shenzhen Grubbs Institute, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China

4. Academy for Advanced Interdisciplinary Studies and Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China

Abstract

A rare hetero-ene mechanism has been computationally elucidated to enable the activation of unactivated alkenes by moderately strong chiral N-triflylphosphoramide Brønsted acid catalysts.

Funder

National Natural Science Foundation of China

Shenzhen University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Reference122 articles.

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2. A General Approach to Catalytic Alkene Anti-Markovnikov Hydrofunctionalization Reactions via Acridinium Photoredox Catalysis

3. M.Rueping , D.Parmar and E.Sugiono , in Asymmetric Brønsted Acid Catalysis , ed. M. Rueping , D. Parmar and E. Sugiono , Wiley , Weinheim , 2016 , ch. 6, pp. 161–182

4. Recent developments in alkene hydro-functionalisation promoted by homogeneous catalysts based on earth abundant elements: formation of C–N, C–O and C–P bond

5. Hydrofunctionalization , ed. V. P. Ananikov and M. Tanaka , Springer , Berlin, Heidelberg , 2013

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