Transition-metal-free nucleophilic 211At-astatination of spirocyclic aryliodonium ylides

Author:

Matsuoka Keitaro1234,Obata Honoka12345,Nagatsu Kotaro56784,Kojima Masahiro1234,Yoshino Tatsuhiko1234ORCID,Ogawa Mikako12349,Matsunaga Shigeki12349ORCID

Affiliation:

1. Faculty of Pharmaceutical Science

2. Hokkaido University

3. Sapporo 060-0812

4. Japan

5. Department of Advanced Nuclear Medicine Sciences

6. Institute for Quantum Medical Science

7. National Institutes for Quantum and Radiological Science and Technology

8. Chiba

9. Global Station for Biosurfaces and Drug Discovery

Abstract

The transition-metal-free nucleophilic 211At-astatination of aryliodonium ylides, involving those derived from multi-functionalized molecules and heteroarenes, proceeded with good to excellent radiochemical yields.

Funder

Japan Society for the Promotion of Science

Adaptable and Seamless Technology Transfer Program through Target-Driven R and D

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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