A regioselective [4 + 2] annulation approach to 5-acylindolizine-7-carbonitriles: generation of poly-substituted pyridines-Reference-Cited by-同舟云学术

A regioselective [4 + 2] annulation approach to 5-acylindolizine-7-carbonitriles: generation of poly-substituted pyridines

Published:2021 Issue:26 Volume:19 Page:5806-5817
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kim Sunmi¹²³⁴,Lee Jeong Hwa¹²³⁴,Yoon Seok Hyun⁵²³⁴^ORCID,Kim Ikyon¹²³⁴^ORCID

Affiliation:

1. College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences

2. Yonsei University

3. Incheon

4. Republic of Korea

5. Graduate Program of Industrial Pharmaceutical Sciences

Abstract

A highly efficient [4 + 2] annulation approach to poly-functionalized indolizine-7-carbonitriles enables us to install nitrile, (hetero)aryl/alkyl, and acyl groups regioselectively on the pyridine unit of indolizine.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00788B

Reference45 articles.

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4. Chemical space and biology

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