Synthesis and functionalization of dendritic polyglycerol-based nanogels: application in T cell activation-Reference-Cited by-同舟云学术

Synthesis and functionalization of dendritic polyglycerol-based nanogels: application in T cell activation

Published:2022 Issue:1 Volume:10 Page:96-106
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Reisbeck Felix¹,Wedepohl Stefanie¹^ORCID,Dimde Mathias¹,Schmitt Ann-Cathrin¹,Dernedde Jens²^ORCID,Álvaro-Benito Miguel³^ORCID,Freund Christian³^ORCID,Haag Rainer¹^ORCID

Affiliation:

1. Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany

2. Charité-Universitätsmedizin Berlin, Insitute of Laboratory Medicine, Clinical Chemistry, and Pathobiochemistry, CVK Augustenburger Platz 1, 13535 Berlin, Germany

3. Institute of Chemistry and Biochemistry, Freie Universität Berlin, Thielallee 63, 14195 Berlin, Germany

Abstract

Synthesis of a dPG- and NG-based nanoplatform conjugated to avidin for the multivalent display of biotinylated biomolecules. Carriers were coupled to antibodies and their capability to activate T cells was assessed, showing a multivalency effect.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D1TB02144C

Reference50 articles.

1. Multivalency as a Chemical Organization and Action Principle

2. Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors

3. Polymer–drug conjugate therapeutics: advances, insights and prospects